Reaktion #64934

Reaktionsgleichung

3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane

2-aminoethanol

→

trans-1-Benzyl-4-hydroxy-3-(2-hydroxyethylamino)pyrrolidine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe solution is extracted once with tert.-butyl methyl ether
2. 2
   Einengenthe aqueous phase is concentrated
3. 3
   workup.DISTILLATIONThe residue is distilled

Vorschrift

40 g (0.22 mol) of 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 42 g (0.68 mol) of 2-aminoethanol in 450 ml of water overnight. The solution is extracted once with tert.-butyl methyl ether and the aqueous phase is concentrated. The residue is distilled.

Quelle