Reaktion #64906

Reaktionsgleichung

water

8-azaphenanthrene-1,10-dicarboxylic anhydride

sodium nitrate

→

nitro

Ausbeute 66.0%

3-Nitro-8-azaphenanthrene-1,10-dicarboxylic Anhydride

Ausbeute 66.0%

Lösungsmittel

sulfuric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenrinsing the residue from the reaction flask with water (4×25 mL)
2. 2
   workup.ADDITIONwas added as a buffer
3. 3
   SonstigeThe precipitated solid was collected on a frit
4. 4
   Sonstigedried
5. 5
   TemperaturThe crude material was heated
6. 6
   Temperaturat reflux in acetic acid (70 mL)
7. 7
   SonstigeThe brown solid was collected on a frit
8. 8
   Waschenwashed with acetic acid (20 mL)
9. 9
   Sonstigedried

Vorschrift

As above for example 2, part A, 8-azaphenanthrene-1,10-dicarboxylic anhydride (7.62 g, 30.6 mmol) was nitrated in concentrated sulfuric acid (30 mL) at 110° C. by the addition of sodium nitrate (6.50 g, 76.5 mmol) in five portions over 31 h. The acid solution was poured into water (300 mL), rinsing the residue from the reaction flask with water (4×25 mL). The aqueous suspension was neutralized to about pH 4 with concentrated sodium hydroxide solution and sodium acetate (5 g) was added as a buffer. The precipitated solid was collected on a frit and dried. The crude material was heated at reflux in acetic acid (70 mL) and acetic anhydride (10 mL) for 4 h and the suspension was cooled to room temperature. The brown solid was collected on a frit, washed with acetic acid (20 mL), and dried to give 5.94 g (66%) of the nitro compound: mp >300° C.; 1H NMR (CDCl3, 300 MHz) δ 7.97 (dd, 1H, J=9.0, 4.5 Hz), 9.16 (d, 1H, J=9.0 Hz), 9.33 (d, 1H, J=4.5 Hz), 9.42 (s, 1H), 9.48 (d, 1H, J=1.5 Hz), 9.87 (d, 1H, J=1.5 Hz); MS (CI, CH4) m/e (%) 295 (M+H+, 100), 250 (4), 121 (6), 103 (4), 93 (19).

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