Reaktion #64846

ord-d9b3e31b5faf42ceb8283b36db1ef77b

Reaktionsgleichung

C=CC(=O)N1Cc2ccccc2SC(Cl)C1
4-acryloyl-2-chloro-2,3,4,5-tetrahydro-1,4-benzothiazepine
CC(C)=CCC/C(C)=C/CO
geraniol
→
C=CC(=O)N1Cc2ccccc2SC(OC/C=C(\C)CCC=C(C)C)C1
4-acryloyl-2-geranyloxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
Ausbeute 68.3%

Edukte

C=CC(=O)N1Cc2ccccc2SC(Cl)C1
4-acryloyl-2-chloro-2,3,4,5-tetrahydro-1,4-benzothiazepine
CC(C)=CCC/C(C)=C/CO
geraniol

Reagenzien

[Cl-].[Cl-].[Zn+2]
zinc chloride

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The above-mentioned 4-acryloyl-2-chloro-2,3,4,5-tetrahydro-1,4-benzothiazepine (1.0 g), geraniol (0.9 g) and zinc chloride (0.8 g) were reacted in the same manner as in Experimental Example 9 to give 4-acryloyl-2-geranyloxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (1.0 g).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05416066uspto-grants-1995_05