Reaktion #64841

Reaktionsgleichung

7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

acryloyl chloride

→

4-acryloyl-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

Ausbeute 83.0%

Lösungsmittel

triethylamine

Reaktionsbedingungen

Vorschrift

7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (10.0 g) (refer to preparation examples 1 to 6 as mentioned below), triethylamine (10.2 g) and acryloyl chloride (6.9 g) were reacted in the same manner as in Experimental Example 1 to give 4-acryloyl-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (10.6 g).

Quelle