Reaktion #648230

Reaktionsgleichung

3-(3,4-difluoro-benzenesulfonyl)-7-nitro-quinolin-4-ol

phosphorus(V) oxybromide

sodium hydroxide

→

title compound

Ausbeute 67.0%

4-Bromo-3-(3,4-difluoro-benzenesulfonyl)-7-nitro-quinoline

Ausbeute 67.0%

Lösungsmittel

DMF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling the precipitate
2. 2
   Filtrationwas filtered
3. 3
   Waschenwashed with water
4. 4
   SonstigeThe obtained crude product
5. 5
   Sonstigewas purified by crystallization from ethanol

Vorschrift

A mixture of 3-(3,4-difluoro-benzenesulfonyl)-7-nitro-quinolin-4-ol (1.6 g, 4.37 mmol) and phosphorus(V) oxybromide (2.5 g, 8.72 mmol) in DMF (16 ml) was stirred at 65° C. for 1 hour. The reaction mixture was diluted with water (100 ml) and the pH was adjusted to 10 with aqueous sodium hydroxide solution. After cooling the precipitate was filtered and washed with water. The obtained crude product was purified by crystallization from ethanol to obtain 1.25 g of the title compound in 67% yield.

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