Reaktion #64780

Reaktionsgleichung

bis(trimethylsilyl)trifluoroacetamide

L-aspartic acid

2-trifluoromethyl-3-acetylthiopropionyl chloride

dimethylformamide

→

title compound

N-[2-[(Acetylthio)methyl]-3,3,3-trifluoro-1-oxopropyl]-L-aspartic acid

Lösungsmittel

acetonitrile

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturgradually warmed to room temperature overnight
2. 2
   workup.STIRRINGthe mixture was stirred for 2 hours
3. 3
   TemperaturThe resultant clear, light yellow solution was cooled to 5° C.
4. 4
   workup.ADDITIONwas added dropwise
5. 5
   workup.STIRRINGto stir
6. 6
   Temperaturwarm to room temperature overnight
7. 7
   Sonstigethe solvent was evaporated
8. 8
   SonstigeThe yellow syrupy residue was partitioned between water (50 mL) and ethyl acetate (50 mL)
9. 9
   Sonstigethe organic layer was separated
10. 10
    ExtraktionThe aqueous phase was further extracted with ethyl acetate (3×50 mL)
11. 11
    Extraktionthe combined ethyl acetate extract
12. 12
    Waschenwas washed with brine
13. 13
    Trocknendried (MgSO4)
14. 14
    Sonstigeevaporated
15. 15
    Sonstigeto yield 12.2 g
16. 16
    WaschenFlash chromatography on silica gel (125:1 silica gel to compound) eluting with ethyl acetate
17. 17
    Sonstigeacetic acid, 15:1 gave 5.25 g

Vorschrift

A stirred suspension of L-aspartic acid (2.66 g., 20 mmol.) in 35 mL of dry acetonitrile under argon was cooled to 0° C. and bis(trimethylsilyl)trifluoroacetamide (10.62 mL, 40 mmol) was added. The reaction mixture was allowed to stir and gradually warmed to room temperature overnight, and then 5 mL of dimethylformamide was added and the mixture was stirred for 2 hours. The resultant clear, light yellow solution was cooled to 5° C. and 2-trifluoromethyl-3-acetylthiopropionyl chloride (4.69 g., 20 mmol), dissolved in 6 mL of acetonitrile, was added dropwise. The reaction mixture was allowed to stir and warm to room temperature overnight, and then the solvent was evaporated. The yellow syrupy residue was partitioned between water (50 mL) and ethyl acetate (50 mL), and the organic layer was separated. The aqueous phase was further extracted with ethyl acetate (3×50 mL) and the combined ethyl acetate extract was washed with brine, dried (MgSO4) and evaporated to yield 12.2 g. of a light yellow residue. Flash chromatography on silica gel (125:1 silica gel to compound) eluting with ethyl acetate:acetic acid, 15:1 gave 5.25 g. of a major fraction which was a light yellow sticky solid and 0.63 g. fraction which was nearly homogeneous by TLC, for a total of 5.88 g. of the title compound as a mixture of diastereomers.

Quelle