Reaktion #64770

ord-5c92a31500f442ccacf5c8bb99184d6e

Reaktionsgleichung

CCOC(=O)c1ccc(C=CC(=O)O)cc1
4-carbethoxycinnamic acid
→
CCOC(=O)c1ccc(CCC(=O)O)cc1
title compound
Ausbeute 46.0%
CCOC(=O)c1ccc(CCC(=O)O)cc1
4-Ethoxycarbonylbenzenepropanoic acid
Ausbeute 46.0%

Edukte

CCOC(=O)c1ccc(C=CC(=O)O)cc1
4-carbethoxycinnamic acid

Reagenzien

[Rh]
Rh/C

Lösungsmittel

CCO
EtOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe solution filtered
  2. 2
    SonstigeThe residue was crystallized from cyclohexane

Vorschrift

A solution of 4-carbethoxycinnamic acid (4.9 g) in EtOH (120 ml) was hydrogenated over 5% Rh/C (485 mg) at atmospheric pressure for 21 hr. The solution filtered and stripped. The residue was crystallized from cyclohexane to afford 2.23 g (46%) of the title compound as white crystals; mp 108.5°-110.5°.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05414132uspto-grants-1995_05