Reaktion #647629

ord-4fb329904230464fb87f58644f64acee

Reaktionsgleichung

Cc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c(-c2cccc(Cl)c2)s1
((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone
O=C(O)c1scc2c1OCCO2
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid
→
Cc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2scc3c2OCCO3)c(-c2cccc(Cl)c2)s1
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid{(1S,2S,5R)-3-[5-(3-chloro-phenyl)-2-methyl-thiazole-4-carbonyl]-3-aza-bicyclo[3.1.0]hex-2-ylmethyl}-amide

Edukte

Cc1nc(C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c(-c2cccc(Cl)c2)s1
((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone
O=C(O)c1scc2c1OCCO2
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-[5-(3-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanone with 2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid. LC-MS (basic): tR=0.86 min; [M+H]+=516.3.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11