Reaktion #647599

ord-119e102c090f4441891ac53cd9eb84e2

Reaktionsgleichung

Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1
((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone
O=C(O)c1scc2c1OCCO2
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid
→
Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2scc3c2OCCO3)c1
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic Acid[(1S,2S,5R)-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Edukte

Cc1cccc(-c2sc(C)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CN)c1
((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone
O=C(O)c1scc2c1OCCO2
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of ((1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid. LC-MS (basic): tR=0.85 min; [M+H]+=496.3.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11