Reaktion #647562

ord-102ab30bd5db4ba4b76af0f7ce62d0f2

Reaktionsgleichung

Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2C[C@@H]21
6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide
O=C(O)c1ccccc1-n1cccn1
2-Pyrazol-1-yl-benzoic acid
→
Cc1nc2sccn2c1C(=O)NC[C@@H]1[C@H]2C[C@H]2CN1C(=O)c1ccccc1-n1cccn1
6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1S,2S,5R)-3-(2-pyrazol-1-yl-benzoyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Edukte

Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2C[C@@H]21
6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide
O=C(O)c1ccccc1-n1cccn1
2-Pyrazol-1-yl-benzoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid [(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 2-Pyrazol-1-yl-benzoic acid. LC-MS (basic): tR=1.20 min; [M+H]+=447.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11