Reaktion #647552

ord-bc42c881cc9d4cb38a02dc11a35198f0

Reaktionsgleichung

Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2C[C@@H]21
6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide
Cc1cccc(-c2sc(N)nc2C(=O)O)c1
2-Amino-5-m-tolyl-thiazole-4-carboxylic acid
→
Cc1cccc(-c2sc(N)nc2C(=O)N2C[C@@H]3C[C@@H]3[C@H]2CNC(=O)c2c(C)nc3sccn23)c1
6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1S,2S,5R)-3-(2-amino-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide

Edukte

Cc1nc2sccn2c1C(=O)NC[C@H]1NC[C@@H]2C[C@@H]21
6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide
Cc1cccc(-c2sc(N)nc2C(=O)O)c1
2-Amino-5-m-tolyl-thiazole-4-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[(1S,2S,5R)-1-(3-aza-bicyclo[3.1.0]hex-2-yl)methyl]-amide with 2-Amino-5-m-tolyl-thiazole-4-carboxylic acid. LC-MS (basic): tR=1.24 min; [M+H]+=493.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11