Reaktion #647526

ord-c2d3594c6eec4afe8cdb073990223879

Reaktionsgleichung

CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1CN
(1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester
O=C(O)c1scc2c1OCCO2
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid
→
CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1CNC(=O)c1scc2c1OCCO2
(1S,2S,5R)-2-{[(2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic Acid Tert-butyl Ester

Edukte

CC(C)(C)OC(=O)N1C[C@@H]2C[C@@H]2[C@H]1CN
(1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester
O=C(O)c1scc2c1OCCO2
2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of (1S,2S,5R)-2-Aminomethyl-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester with 2,3-Dihydro-thieno[3,4-b][1,4]dioxine-5-carboxylic acid. LC-MS: tR=0.96 min; [M+H]+=381.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11