Reaktion #647445

ord-7b697c5bb44c4e1cba69435b309a22b2

Reaktionsgleichung

COC(=O)c1nc(Br)sc1-c1cccc(C)c1
2-bromo-5-m-tolyl-thiazole-4-carboxylic acid methyl ester
CNC
dimethylamine
→
Cc1cccc(-c2sc(N(C)C)nc2C(=O)O)c1
2-Dimethylamino-5-m-tolyl-thiazole-4-carboxylic Acid

Edukte

COC(=O)c1nc(Br)sc1-c1cccc(C)c1
2-bromo-5-m-tolyl-thiazole-4-carboxylic acid methyl ester
CNC
dimethylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 2-bromo-5-m-tolyl-thiazole-4-carboxylic acid methyl ester with dimethylamine. LC-MS: tR=0.85 min; [M+H]+=263.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11