Reaktion #647438

ord-918c52b6c2354828b86bb0c9d2daf90d

Reaktionsgleichung

COC(=O)C(=O)C(Cl)c1cccc(C(F)(F)F)c1
3-chloro-3-(3-trifluoromethyl-phenyl)-2-oxo-propionic acid methyl ester
NC(N)=S
thiourea
→
COC(=O)c1nc(N)sc1-c1cccc(C(F)(F)F)c1
2-Amino-5-(3-trifluoromethyl-phenyl)-thiazole-4-carboxylic Acid Methyl Ester

Edukte

COC(=O)C(=O)C(Cl)c1cccc(C(F)(F)F)c1
3-chloro-3-(3-trifluoromethyl-phenyl)-2-oxo-propionic acid methyl ester
NC(N)=S
thiourea

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 3-chloro-3-(3-trifluoromethyl-phenyl)-2-oxo-propionic acid methyl ester with thiourea. LC-MS: tR=0.86 min; [M+H]+=303.3.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11