Reaktion #647422

ord-cb160654c9f84a219b53b30ace98dfa7

Reaktionsgleichung

COC(=O)C(=O)C(Cl)c1ccc(F)c(F)c1
3-chloro-3-(3,4-difluoro-phenyl)-2-oxo-propionic acid methyl ester
CC(N)=S
thioacetamide
→
COC(=O)c1nc(C)sc1-c1ccc(F)c(F)c1
5-(3,4-Difluoro-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester

Edukte

COC(=O)C(=O)C(Cl)c1ccc(F)c(F)c1
3-chloro-3-(3,4-difluoro-phenyl)-2-oxo-propionic acid methyl ester
CC(N)=S
thioacetamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

prepared by reaction of 3-chloro-3-(3,4-difluoro-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.92 min; [M+H]+=270.3.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063099B2uspto-grants-2011_11