Reaktion #64722

Reaktionsgleichung

1-(2-chlorophenyl)piperazine

triethylamine

2-[bis(4-hydroxyphenyl)methyl]benzylbromide

→

desired compound

Ausbeute 14.6%

1-(2-Chlorophenyl)-4-{2-[bis(4-hydroxyphenyl)methyl]benzyl}piperazine

Ausbeute 14.6%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturThe mixture was heated
3. 3
   Temperaturunder reflux for 3.5 hours
4. 4
   Filtrationinsoluble substances were filtered off
5. 5
   EinengenThe filtrate was concentrated
6. 6
   Extraktionthe residue was subjected to extraction with the addition of water and ethyl acetate
7. 7
   SonstigeThe organic layer was separated
8. 8
   Extraktionthe aqueous layer was then extracted with ethyl acetate
9. 9
   Trocknendried over anhydrous magnesium sulfate
10. 10
    SonstigeThe solvent was evaporated off under reduced pressure
11. 11
    Sonstigethe residue was purified by silica gel chromatography

Vorschrift

In 50 ml of tetrahydrofuran were dissolved 1.5 g of 1-(2-chlorophenyl)piperazine and 5 ml of triethylamine, and 3.4 g of 2-[bis(4-hydroxyphenyl)methyl]benzylbromide was added thereto. The mixture was heated under reflux for 3.5 hours, and then insoluble substances were filtered off. The filtrate was concentrated, and the residue was subjected to extraction with the addition of water and ethyl acetate. The organic layer was separated, and the aqueous layer was then extracted with ethyl acetate. The organic layers were combined and then dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel chromatography to afford 0.54 g of the desired compound (Compound 89).

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