Reaktion #647069

Reaktionsgleichung

2-(2-methoxy-phenoxy)-4,5-difluoroaniline

2,3-dimethoxyphenol

1,3,4-trifluoronitrobenzene

2-(2,3-dimethoxyphenoxy)-4,5-difluoroaniline

2-aminothiazole

→

N-[4,5-Difluoro-2-(2,3-dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea

Ausbeute 89.0%

4,5-Difluoro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene

Ausbeute 90.3%

Reaktionsbedingungen

Vorschrift

4,5-Difluoro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene (1.4 g, 90.3%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 1,3,4-trifluoronitrobenzene (0.885 g, 5.0 mmol) following the general procedure F. The product was then reduced to 2-(2-methoxy-phenoxy)-4,5-difluoroaniline (1.35 g, 96.1%) following general procedure B. N-[4,5-Difluoro-2-(2,3-dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (0.181 g, 89%) was prepared from 2-(2,3-dimethoxyphenoxy)-4,5-difluoroaniline (0.140 g, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.

Quelle