Reaktion #647049

Reaktionsgleichung

5-fluoro-2-(2-methylsulfanyl-phenoxy)aniline

2-hydroxythioanisole

2,5-difluoro-1-nitrobenzene

5-fluoro-2-(2-methylsulfanylphenoxy)aniline

2-aminothiazole

→

N-[5-Fluoro-2-(2-methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea

Ausbeute 65.0%

5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene

Ausbeute 68.0%

Reaktionsbedingungen

Vorschrift

5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene (0.95 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 5-fluoro-2-(2-methylsulfanyl-phenoxy)aniline (0.52 g, 62%) following general procedure B. N-[5-Fluoro-2-(2-methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (120 mg, 65%) was prepared from 5-fluoro-2-(2-methylsulfanylphenoxy)aniline (125 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Quelle