Reaktion #646441

ord-6c414e8680034fa39374d32c339edbc3

Reaktionsgleichung

Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2c3cc(-c4csc(C=O)n4)ccc3n(C)c21
4-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-thiazole-2-carbaldehyde
[CH3][Mg][Br]
methylmagnesium bromide
→
CC(O)c1nc(-c2ccc3c(c2)c2cc(-c4ccc(Cl)cc4Cl)c(=O)n(C)c2n3C)cs1
3-(2,4-Dichlorophenyl)-6-[2-(1-hydroxyethyl)thiazol-4-yl]-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one

Edukte

—
compound A
Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2c3cc(-c4csc(C=O)n4)ccc3n(C)c21
4-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-thiazole-2-carbaldehyde
[CH3][Mg][Br]
methylmagnesium bromide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The process is carried out as indicated in Example 139 above, with compound A, 4-[3-(2,4-dichlorophenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indol-6-yl]-thiazole-2-carbaldehyde, and methylmagnesium bromide.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063061B2uspto-grants-2011_11