Reaktion #646413

ord-f777992d75fc42908839a272cb18bfc6

Reaktionsgleichung

Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2c3cc(-c4csc(CCl)n4)ccc3n(C)c21
6-(2-chloromethylthiazol-4-yl)-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one
C1COCCN1
morpholine
→
Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2c3cc(-c4csc(CN5CCOCC5)n4)ccc3n(C)c21
3-(2,4-Dichlorophenyl)-1,9-dimethyl-6-(2-morpholin-4-ylmethyl-thiazol-4-yl)-1,9-dihydropyrido[2,3-b]indol-2-one

Edukte

—
compound
Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2c3cc(-c4csc(CCl)n4)ccc3n(C)c21
6-(2-chloromethylthiazol-4-yl)-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one
C1COCCN1
morpholine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The process is carried out as in Example 122 above, with the compound from Example 128A 6-(2-chloromethylthiazol-4-yl)-3-(2,4-dichlorophenyl)-1,9-dimethyl-1,9-dihydropyrido[2,3-b]indol-2-one and morpholine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063061B2uspto-grants-2011_11