Reaktion #64615

ord-e86c6e8a3ef14df394906cd16bf67f82

Reaktionsgleichung

CC(C)(C)NC(=O)[C@@H]1C[C@H](Oc2ccccc2)CN1.O=C(O)C(F)(F)F
N-t-butyl-4(S)-phenoxy-L-prolineamide trifluoroacetic acid salt
Oc1cccc2ccccc12
1-naphthol
Oc1ccccc1
phenol
→
NC(=O)[C@@H]1CCCN1Oc1cccc2ccccc12
1-naphthyloxy proline amide

Edukte

CC(C)(C)NC(=O)[C@@H]1C[C@H](Oc2ccccc2)CN1.O=C(O)C(F)(F)F
N-t-butyl-4(S)-phenoxy-L-prolineamide trifluoroacetic acid salt
Oc1cccc2ccccc12
1-naphthol
Oc1ccccc1
phenol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following substantially the same procedure for synthesizing N-t-butyl-4(S)-phenoxy-L-prolineamide trifluoroacetic acid salt as outlined in Example 1, Steps 6 through 8, but substituting 1-naphthol for the phenol used therein, the 1-naphthyloxy proline amide was produced.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05413999uspto-grants-1995_05