Reaktion #64594

Reaktionsgleichung

Glycine

Triethylamine

1-bromododecane

→

N-n-dodecylglycine

Ausbeute 26.3%

Lösungsmittel

IPA

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter the solvent was removed
2. 2
   workup.ADDITIONTHF was added to the remaining material
3. 3
   SonstigeTriethylamine hydrobromide was removed by filtration
4. 4
   Einengenthe filtrate was concentrated

Vorschrift

Glycine was dissolved in a 2:1 mixture by volume of IPA and water. Triethylamine and 1-bromododecane were added to the solution successively and the mixture was kept stirring for more than 7 days. After the solvent was removed, THF was added to the remaining material. Triethylamine hydrobromide was removed by filtration and the filtrate was concentrated. N-n-dodecylglycine was obtained from the concentrated solution by separation and purification by column chromatography with the yield of 26.3%.

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