Reaktion #64593

Reaktionsgleichung

glycine

sodium hydroxide

n-dodecanoyl chloride

sodium hydroxide

hydrochloric acid

→

N-n-dodecanoylglycine

Ausbeute 84.7%

Lösungsmittel

ether

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed from the solution

Vorschrift

To a solution of glycine in a 1 N-sodium hydroxide, an ether solution of n-dodecanoyl chloride and a 1 N-aqueous solution of sodium hydroxide were dropped simultaneously and the mixture was stirred for 1 hour. The reaction mixture was then neutralized with hydrochloric acid and ether was removed from the solution. N-n-dodecanoylglycine was obtained from the remaining reactant after the purification by column chromatography with the yield of 84.7 %. The melting point of the product was 115.5° to 116.7° C.

Quelle