Reaktion #6459

Reaktionsgleichung

2-(2-Phenoxyphenyl)-2-methoxyiminoacetamide

Trifluoroacetic anhydride

→

2-(2-phenoxyphenyl)-2-methoxyiminoacetonitrile

Ausbeute 96.9%

Lösungsmittel

hydrochloric acid

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   SonstigeThe extract was dried
3. 3
   Einengenconcentrated
4. 4
   Sonstigeto leave a residue, which
5. 5
   Sonstigewas purified by column chromatography on silica gel

Vorschrift

2-(2-Phenoxyphenyl)-2-methoxyiminoacetamide (3.77 g) was dissolved in pyridine (5.53 g). The solution was cooled to 0° C. Trifluoroacetic anhydride (4.40 g) was added dropwise. The mixture was stirred for 2 hours at 0° C., and then diluted with dil. hydrochloric acid and extracted with ethyl acetate. The extract was dried and concentrated to leave a residue, which was purified by column chromatography on silica gel to obtain 2-(2-phenoxyphenyl)-2-methoxyiminoacetonitrile (3.41 g).

Quelle