Reaktion #645838

ord-5ce452c662344e89be0c7414835055db

Reaktionsgleichung

C#Cc1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12
3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine
Brc1ccc(C2CC2)nc1
5-bromo-2-cyclopropyl-pyridine
→
FC(F)(F)c1ccc(-c2cc(C(F)(F)F)n3ncc(C#Cc4ccc(C5CC5)nc4)c3n2)cc1
title compound
FC(F)(F)c1ccc(-c2cc(C(F)(F)F)n3ncc(C#Cc4ccc(C5CC5)nc4)c3n2)cc1
3-(2-Cyclopropyl-pyridin-5-ylethynyl)-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Edukte

C#Cc1cnn2c(C(F)(F)F)cc(-c3ccc(C(F)(F)F)cc3)nc12
3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine
Brc1ccc(C2CC2)nc1
5-bromo-2-cyclopropyl-pyridine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 3-ethynyl-7-trifluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.1) (355 mg, 1.0 mmol) and 5-bromo-2-cyclopropyl-pyridine (Example B.11) (257 mg, 1.3 mmol) according to general procedure II. Obtained as an orange solid (110 mg, 23%). MS (ISP) 473.0 [(M+H)+]; mp 138-140° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08063048B2uspto-grants-2011_11