Reaktion #6457

Reaktionsgleichung

benzo-1,2,3-thiadiazole-7-carboxylic acid chloride

tetrahydrofuran

malonate

triethylamine

→

title compound

benzo-1,2,3-thiadiazol-7-yl-2,2-dimethyl-1,3-dioxane-4,6-dione

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate

Vorschrift

5.5 g of benzo-1,2,3-thiadiazole-7-carboxylic acid chloride in 10 ml of tetrahydrofuran are added dropwise to a solution, stirred at 0° C., of 3.6 g of cycloisopropylidene malonate, 7.6 ml of triethylamine and 2.0 g of 4-dimethylaminopyridine in 25 ml of dichloromethane. The reaction mixture is stirred for 2 hours at 0° C. and then applied directly to a silica gel column and extracted with ethyl acetate, resulting in the title compound in the form of a salt with 4-dimethylaminopyridine (2:1), m.p. 170°-172° C.

Quelle