Reaktion #645649

Reaktionsgleichung

3-bromo-2-chloro-4-picoline

formic acid

water

→

3-bromo-4-methylpyridin-2(1H)-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe tube was sealed
2. 2
   Temperaturthe solution was cooled to RT
3. 3
   Einengenconcentrated in vacuo
4. 4
   SonstigeThe residue was purified by reverse phase chromatography (neutral)

Vorschrift

To a resealable pressure vessel charged with 3-bromo-2-chloro-4-picoline (1.200 g, 5.81 mmol) was added formic acid (13.1 ml, 348 mmol) and water (4.00 ml, 222 mmol). The tube was sealed and the solution heated to 120° C. After 72 hrs, the solution was cooled to RT and concentrated in vacuo. The residue was purified by reverse phase chromatography (neutral) to afford 3-bromo-4-methylpyridin-2(1H)-one as a white solid. M+H+=188.0.

Quelle