Reaktion #645228

Reaktionsgleichung

Triphenylsulfonium 2-(pivaloyloxy)-1,1-difluoroethanesulfonate

sodium hydroxide

hydrochloric acid

→

triphenylsulfonium 1,1-difluoro-2-hydroxy-ethanesulfonate

Ausbeute 78.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturice cooled
2. 2
   Sonstigeto quench
3. 3
   Sonstigethe reaction
4. 4
   workup.DISTILLATIONMethanol was distilled off in vacuum
5. 5
   workup.ADDITIONafter which 1,000 g of dichloromethane was added to the residue
6. 6
   WaschenThe organic layer was washed three times with 30 g of saturated sodium chloride water
7. 7
   EinengenThe organic layer was concentrated
8. 8
   workup.ADDITIONafter which 1 L of diisopropyl ether was added to the
9. 9
   Einengenconcentrate for crystallization
10. 10
    FiltrationThe crystals were filtered
11. 11
    Sonstigedried
12. 12
    Sonstigeobtaining the target compound

Vorschrift

Triphenylsulfonium 2-(pivaloyloxy)-1,1-difluoroethanesulfonate, 243.5 g (0.48 mol), was dissolved in 760 g of methanol and ice cooled. A sodium hydroxide solution (40 g of sodium hydroxide in 120 g of water) was added dropwise to the solution at a temperature below 5° C. It was aged at room temperature for 8 hours. At a temperature below 10° C., dilute hydrochloric acid (99.8 g of 12N hydrochloric acid in 200 g of water) was added to the mixture to quench the reaction. Methanol was distilled off in vacuum, after which 1,000 g of dichloromethane was added to the residue. The organic layer was washed three times with 30 g of saturated sodium chloride water. The organic layer was concentrated, after which 1 L of diisopropyl ether was added to the concentrate for crystallization. The crystals were filtered and dried, obtaining the target compound. 187 g (purity 78%, net yield 78%).

Quelle