Reaktion #645226

Reaktionsgleichung

Pivalic chloride

2-bromo-2,2-difluoroethanol

Triethylamine

→

2-bromo-2,2-difluoroethyl pivalate

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturice cooled
2. 2
   workup.DISTILLATIONSubsequent standard separatory operation and solvent distillation

Vorschrift

Pivalic chloride and 2-bromo-2,2-difluoroethanol were mixed in tetrahydrofuran and ice cooled. Triethylamine was added to the mixture. Subsequent standard separatory operation and solvent distillation gave 2-bromo-2,2-difluoroethyl pivalate. This compound was converted into a sodium sulfinate using sodium dithionite and then oxidized with hydrogen peroxide, yielding the target compound, sodium 2-(pivaloyloxy)-1,1-difluoroethanesulfonate.

Quelle