Reaktion #645105

Reaktionsgleichung

Lithium tetrahydroaluminate

methyl (2S,4R)-4-phenylpyrrolidine-2-carboxylate

→

desired product

[(2S,4R)-4-phenylpyrrolidin-2-yl]methanol

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen the ice-water bath was removed
2. 2
   Sonstigewas quenched with brine (1 mL)
3. 3
   ExtraktionThe resulting mixture was extracted with ethyl acetate (2×2 mL)
4. 4
   WaschenThe combined organic layer was washed with brine
5. 5
   Trocknendried over Na2SO4
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated under reduced pressure

Vorschrift

Lithium tetrahydroaluminate in tetrahydrofuran (1.00 M, 1.00 mL) was added to methyl (2S,4R)-4-phenylpyrrolidine-2-carboxylate (103.0 mg, 0.0005018 mol) in tetrahydrofuran (3.00 mL, 0.0370 mol) at 0° C. Then the ice-water bath was removed and the reaction mixture was stirred at rt for 1 h and was quenched with brine (1 mL). The resulting mixture was extracted with ethyl acetate (2×2 mL). The combined organic layer was washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give the desired product which was directly used in the next step without further purification.

Quelle