Reaktion #644987
ord-b1c2ea85f9bc4a73b6471a3d2e012482
Reaktionsgleichung
Hunig base
1-(4-chlorophenyl)cyclopropanecarboxylic acid
BOP reagent
2-phenylpyrrolidine
→
1-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-2-phenylpyrrolidine
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1Sonstigedirectly purified by flash column
Vorschrift
To a solution of 30 mg of 1-(4-chlorophenyl)cyclopropanecarboxylic acid and 81 mg BOP reagent in 0.5 mL methylene chloride wad added 27 mg of 2-phenylpyrrolidine, followed by the addition of 53 ul of Hunig base. The reaction mixture was stirred at r.t. for 2 hours and directly purified by flash column using ethyl/hexane as the eluting solvent to provide the desired 1-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-2-phenylpyrrolidine. LCMS (ESI): 326.1 (M+H+).