Reaktion #64450

Reaktionsgleichung

5-[4'-(bromomethyl)biphenyl-2-yl]-N-trityltetrazole

lithium azide

→

white crystals

Ausbeute 83.0%

5-[4'-(Azidomethyl)biphenyl-2-yl]-N-trityltetrazole

Ausbeute 83.0%

Lösungsmittel

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONWithin a few minutes virtually all of the solid had dissolved
2. 2
   Sonstigethis was followed immediately by precipitation of product
3. 3
   SonstigeAfter 4 hours the solid was collected on
4. 4
   Filtrationa filter
5. 5
   Waschenwashed with some methanol
6. 6
   SonstigeThe solid was air-dried overnight
7. 7
   Sonstigedried further in a vacuum oven at 70° C. (<1 mm)

Vorschrift

To a stirred suspension of 11.15 g (20 mmole) of 5-[4'-(bromomethyl)biphenyl-2-yl]-N-trityltetrazole [P. E. Aldrich, M. E. Pierce, and J. J. V. Duncia, European Patent Application 291,969 (1988)]in 55 ml of dry DMSO was added 1.23 g (25 mmole) of freshly pulverized lithium azide, and the mixture was stirred at room temperature under N2. Within a few minutes virtually all of the solid had dissolved, accompanied by a mild exotherm, and this was followed immediately by precipitation of product. After 4 hours the solid was collected on a filter and washed with some methanol, then with a relatively large volume of H2O, and finally again with methanol. The solid was air-dried overnight and-then dried further in a vacuum oven at 70° C. (<1 mm) to give 8.60 g (83%) of white crystals, mp 139°-140.5° C. dec., satisfactory purity by TLC (9:1 hexane-ethyl acetate) for use in the next step. From the combined filtrate and washes was recovered a less pure second crop (1.68 g of cream-colored crystals, mp 129°-132° C. dec.), which was also usable in the next step. Mass spectrum (FAB) m/e 243 (trityl cation); IR (Nujol) 2100 cm-1.

Quelle