Reaktion #64426

Reaktionsgleichung

1-bromopentane

3-Bromophenol

potassium carbonate

→

3-bromo-phenol

n-pentyl ether

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   Filtrationfiltered
3. 3
   workup.ADDITIONThe filtrate is diluted with ether
4. 4
   Waschenwashed with water and brine
5. 5
   TrocknenAfter drying over magnesium sulfate
6. 6
   Einengenconcentrating
7. 7
   Sonstigethe crude oil obtained
8. 8
   Sonstigeis chromatographed over silica gel
9. 9
   Wascheneluted with 3:2 hexane

Vorschrift

To a solution of 5.0 gm of 3-Bromophenol in 60 mls of dimethylformamide is added 6.0 gm of potassium carbonate followed by 4.3 ml of 1-bromopentane. This mixture is heated to 60° C. for 6 hours and then cooled to room temperature and filtered. The filtrate is diluted with ether and washed with water and brine. After drying over magnesium sulfate and concentrating, the crude oil obtained is chromatographed over silica gel, and eluted with 3:2 hexane:ether to yield 3-bromo-phenol, n-pentyl ether as a clear oil.

Quelle