Reaktion #64418

Reaktionsgleichung

3-pentyloxyphenol

NaH

3-Bromopropanol

→

3-[3-(pentyloxy)phenoxy]propanol

Lösungsmittel

dimethylformamide

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis cooled in an ice bath
2. 2
   SonstigeThe solvent is removed under vacuum
3. 3
   SonstigeThe residue obtained
4. 4
   Sonstigechromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane

Vorschrift

A mixture of 0.80 g of 60% NaH in 28 ml of anhydrous dimethylformamide is cooled in an ice bath. To this is added 3.01 g of the above 3-pentyloxyphenol oil dissolved in 7 ml of anhydrous dimethylformamide. This mixture is then stirred at room temperature for 45 minutes; 1.81 ml of 3-Bromopropanol are added; and the resultant mixture is stirred at 60° C. for 17 hours. The solvent is removed under vacuum, and the residue worked up in same manner as above. The residue obtained is flash chromatographed on normal phase silica gel eluting with a 3:2 ratio of hexane:ether to yield 3-[3-(pentyloxy)phenoxy]propanol as a pale yellow oil.

Quelle