Reaktion #643048

Reaktionsgleichung

4-(3-(tetrahydro-2H-pyran-4-yl)pyrazin-2-yloxy)aniline

2-chlorobenzimidazole

→

N-(4-(3-(tetrahydro-2H-pyran-4-yl)pyrazin-2-yloxy)phenyl)-1H-benzo[d]imidazol-2-amine

Lösungsmittel

IPA

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA glass microwave reaction vessel
2. 2
   Sonstigechromatographed through a Biotage pre-packed silica gel column (40S)
3. 3
   Wascheneluting with a gradient of 1% to 5% MeOH in DCM

Vorschrift

A glass microwave reaction vessel was charged with 4-(3-(tetrahydro-2H-pyran-4-yl)pyrazin-2-yloxy)aniline (0.1536 g, 0.566 mmol) and 2-chlorobenzimidazole (0.095 g, 0.623 mmol) in IPA. The reaction mixture was stirred and heated in a Biotage Initiator microwave reactor at 170° C. for 30 min. The crude product was adsorbed onto a plug of silica gel and chromatographed through a Biotage pre-packed silica gel column (40S), eluting with a gradient of 1% to 5% MeOH in DCM, to provide N-(4-(3-(tetrahydro-2H-pyran-4-yl)pyrazin-2-yloxy)phenyl)-1H-benzo[d]imidazol-2-amine. MS (ESI, pos. ion) m/z: 388.0 (M+1). IC50 (uM) +++++.

Quelle