Reaktion #64296

Reaktionsgleichung

ethyl 2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

methanethiol

methyl 4'-(bromomethyl)-(1,1'-biphenyl)-2 -carboxylate

→

desired product

Ausbeute 69.3%

Ethyl 2-butyl-1-[[2'-(methoxycarbonyl)-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylthio)-1H-imidazole-5-carboxylate

Ausbeute 69.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprepared
2. 2
   Sonstigeas indicated in Stages C and D of Preparation 1

Vorschrift

The operation is carried out as in Example 5, starting with 0.6 g of ethyl 2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate (prepared as indicated in Stages C and D of Preparation 1, replacing the ethanethiol with methanethiol), using 907 mg of methyl 4'-(bromomethyl)-(1,1'-biphenyl)-2 -carboxylate. After chromatography on silica (eluant: methylene chloride--ethyl acetate (97-3)), 0.8 g of the desired product is obtained.

Quelle