Reaktion #6428

ord-709fc48404a84ef09737b5887db2472e

Reaktionsgleichung

CCCCC[C@H]1CC[C@H](COc2ccc(O)c(F)c2F)CC1
2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxyphenol
CCCCBr
butyl bromide
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
CCCCC[C@H]1CC[C@H](COc2ccc(OCCCC)c(F)c2F)CC1
1-butyloxy-2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxybenzene

Edukte

CCCCC[C@H]1CC[C@H](COc2ccc(O)c(F)c2F)CC1
2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxyphenol
CCCCBr
butyl bromide
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
dimethylformamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturAfter cooling
  2. 2
    Filtrationthe inorganic salts are filtered off with suction
  3. 3
    Einengenthe filtrate is concentrated
  4. 4
    workup.ADDITIONwater is added

Vorschrift

0.1 mol of 2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxyphenol, 0.11 mol of butyl bromide and 0.11 mol of potassium carbonate are heated for 16 hours at 100° in 100 ml of dimethylformamide (DMF). After cooling, the inorganic salts are filtered off with suction, the filtrate is concentrated, and water is added. 1-butyloxy-2,3-difluoro-4-(trans-4-pentylcyclohexyl)methoxybenzene is obtained by extraction with dichloromethane.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05248447uspto-grants-1993_09