Reaktion #642776

Reaktionsgleichung

1-(5-hydroxy-1-(4-iodophenyl)-3-methyl-1H-pyrazol-4-yl)-ethanone

2,4-dihydroxybenzoic hydrazide

→

desired product

Ausbeute 94.1%

2,4-dihydroxybenzoic N′-(1-(3-methyl-5-oxo-1-(4-iodophenyl)-1,5-dihydropyrazol-4-ylidene)-ethyl)-hydrazide

Ausbeute 94.1%

Lösungsmittel

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigeevaporation of the solvent
3. 3
   Sonstigethe crude product was recrystallized from chloroform/ether

Vorschrift

1.03 g (3 mmol) of 1-(5-hydroxy-1-(4-iodophenyl)-3-methyl-1H-pyrazol-4-yl)-ethanone and 505 mg (3 mmol) of 2,4-dihydroxybenzoic hydrazide were dissolved in 50 ml of DMSO and heated at 85° C. for 9 hours with stirring. After cooling and evaporation of the solvent, the crude product was recrystallized from chloroform/ether to give 1.39 g of the desired product as a pale brown solid (yield 94%).

Quelle