Reaktion #64276

Reaktionsgleichung

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine

hydrogen chloride

→

hydrogen chloride

1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate

Ausbeute 77.8%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeby bubbling the gas through dry methanol for several minutes
2. 2
   workup.DISSOLUTIONhad completely dissolved (about 13 mL)
3. 3
   workup.WAITAfter the resulting mixture had stood at about 25° C. for several minutes
4. 4
   Sonstigea precipitate formed
5. 5
   TemperaturThe mixture was cooled in an ice bath for thirty minutes
6. 6
   Filtrationthe precipitated solid collected by filtration

Vorschrift

A solution of hydrogen chloride in methanol was prepared by bubbling the gas through dry methanol for several minutes. 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine (1.2 g, 3.1 mmol) was placed in an Erlenmeyer flask, together with a magnetic stirring bar, and the methanolic solution of hydrogen chloride was added until the solid had completely dissolved (about 13 mL). After the resulting mixture had stood at about 25° C. for several minutes, a precipitate formed. The mixture was cooled in an ice bath for thirty minutes and the precipitated solid collected by filtration to yield 1.1 g (2.41 mmol, 77.8%) of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride methanolate.

Quelle