Reaktion #64266

Reaktionsgleichung

HCl

4-nitrobenzoyl chloride

bromobenzene

aluminum chloride

→

yellow crystals

Ausbeute 85.0%

4-bromo-4'-nitrobenzophenone

Ausbeute 85.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 250 mL flask equipped with a nitrogen inlet
2. 2
   Temperaturreflux condenser
3. 3
   Temperaturcooled to room temperature
4. 4
   workup.STIRRINGstirred for an additional 16 h
5. 5
   Extraktionthe organics were extracted
6. 6
   Trocknendried over magnesium sulfate
7. 7
   Sonstigethe solvents were removed under reduced pressure
8. 8
   Sonstigeto yield a yellow powder
9. 9
   SonstigeRecrystallization from acetone

Vorschrift

In a 250 mL flask equipped with a nitrogen inlet, overhead stirring assembly, and reflux condenser were placed 4-nitrobenzoyl chloride (22.6 g, 0.122 mol), bromobenzene (100 g, 0.63 mol), and aluminum chloride (17.3 g, 0.13 mol). The mixture was heated for 3 h at 100° C., then cooled to room temperature and stirred for an additional 16 h. The mixture was poured into 1 L of acidic (HCl) ice water, and the organics were extracted using methylene chloride, dried over magnesium sulfate, and the solvents were removed under reduced pressure to yield a yellow powder. Recrystallization from acetone afforded 29.2 g (85% yield) of yellow crystals: m.p. 123°-124° C., (Lit. 122° C.). ##STR5##

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