Reaktion #642580

Reaktionsgleichung

4-(tert-butyl)-1,2-diaminobenzene

3c

3-Isothiocyanato-2-(3-trifluoromethyl-phenoxy)-pyridine

→

(6-tert-Butyl-1H-benzoimidazol-2-yl)-[2-(3-trifluoromethyl-phenoxy)-pyridin-3-yl]-amine

Lösungsmittel

DCE

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   workup.ADDITIONThe crude mixture containing 3d and 3d′
3. 3
   Sonstigewas used in the next step without further purification

Vorschrift

To a solution of 4-(tert-butyl)-1,2-diaminobenzene (20 mg, 0.12 mmol) in DCE (1 mL) was slowly added 3c (19 mg, 0.06 mmol). The reaction was stirred 18 h at rt and concentrated. The crude mixture containing 3d and 3d′ was used in the next step without further purification.

Quelle