Reaktion #64204

Reaktionsgleichung

cyclopentanone

sodium hydride

5-bromomethylthiophene-2-carbonitrile

triethyl phosphite

→

5-cyclopentylidenemethylthiophene-2-carbonitrile

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen triethyl phosphite is removed at 40°-60°/0.06 mbar
2. 2
   workup.DISTILLATIONthe residue is distilled on a bulb tube at 130°-150°/0.004 mbar
3. 3
   Sonstigeresulting in 24 g of (5-cyano-2-thienyl)methylphosphonic acid diethyl ester
4. 4
   workup.ADDITIONthe mixture is poured on water
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   TrocknenThe ethyl acetate phase is dried
7. 7
   Sonstigeevaporated
8. 8
   Sonstigethe residue is recrystallized from isopropanol

Vorschrift

In a second process, 20 g of 5-bromomethylthiophene-2-carbonitrile is heated with 200 ml of triethyl phosphite for 4 hours to 150°. Then triethyl phosphite is removed at 40°-60°/0.06 mbar, and the residue is distilled on a bulb tube at 130°-150°/0.004 mbar, resulting in 24 g of (5-cyano-2-thienyl)methylphosphonic acid diethyl ester. Of this product, 5 g is added dropwise, with 1.5 ml of cyclopentanone in 5 ml of tetrahydrofuran, to a suspension of 581 mg of sodium hydride/oil (80% strength) and 116 mg of 15-crown-5 in 5 ml of tetrahydrofuran. After 2 hours of agitation at room temperature, the mixture is poured on water and extracted with ethyl acetate. The ethyl acetate phase is dried and evaporated, and the residue is recrystallized from isopropanol, thus obtaining 3.0 g of 5-cyclopentylidenemethylthiophene-2-carbonitrile, identical to the product described above.

Quelle