Reaktion #641703

Reaktionsgleichung

(2-benzyloxy-5-fluorophenyl)-(4-methoxyphenyl)-methanol

HCl

→

title compound

Ausbeute 82.0%

4-Fluoro-2-(4-methoxy-benzyl)phenol

Ausbeute 82.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe catalyst was filtered off
2. 2
   workup.DISTILLATIONThe solvent was distilled under reduced pressure
3. 3
   Sonstigethe obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:6)]

Vorschrift

To a solution of (2-benzyloxy-5-fluorophenyl)-(4-methoxyphenyl)-methanol (0.98 g, 2.90 mmol) in methanol (18.6 mL), a 20% palladium hydroxide catalyst (98 mg) was added and furthermore 2N—HCl (1 mL) was added thereto. The mixture was stirred under a hydrogen atmosphere for 15 hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure, and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:6)] to obtain the title compound (0.55 g, 82%).

Quelle