Reaktion #64116

Reaktionsgleichung

4-chloroquinazoline

sodium hydride

2-(4-chlorophenyl)ethanol

→

4-[2-(4-Chlorophenyl)ethoxy]quinazoline

Ausbeute 2.4%

Lösungsmittel

DMF

water

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred overnight
2. 2
   SonstigeSolid was collected
3. 3
   Sonstigerecrystallized from pentane giving 0.149 g of the title product

Vorschrift

To a solution of 1.1 g of sodium hydride in 50 ml of DMF was added 3.4 g of 2-(4-chlorophenyl)ethanol, and the mixture was stirred at room temperature for one hour. Then 3.6 g of 4-chloroquinazoline in 20 ml of DMF were added, and the mixture was stirred overnight. The mixture was then poured into a mixture of ice in water. Solid was collected and recrystallized from pentane giving 0.149 g of the title product. Yield: 2.4%. M.P. 57°-58° C.

Quelle