Reaktion #6410

Reaktionsgleichung

p-hydroxybenzoic acid

(S)-(-)-2-methylbutanol

sulfuric acid

water

→

ester

Ausbeute 83.0%

2-methylbutyl p-hydroxybenzoate

Ausbeute 83.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed out
2. 2
   WaschenSubsequently, the reaction solution was washed with water
3. 3
   Sonstigeto remove sulfuric acid out
4. 4
   SonstigeAfter the resulting solution was dried
5. 5
   Einengenconcentrated
6. 6
   Sonstigethe concentrate was purified by column chromatography

Vorschrift

4.0 g of p-hydroxybenzoic acid and 12.5 g of (S)-(-)-2-methylbutanol were refluxed for 6 hours in toluene in the presence of sulfuric acid, while the generated water was removed out. Subsequently, the reaction solution was washed with water to remove sulfuric acid out. After the resulting solution was dried and concentrated, the concentrate was purified by column chromatography to obtain 5.0 g of the objective ester compound (liquid state at room temperature, [α]D23 =+4.9° (CHCl3)). (Yield: 83%)

Quelle