Reaktion #64079

Reaktionsgleichung

t-butyl 2-methyl-3hydroxybutanoate

vinyl laurate

→

t-butyl (3S)-2-methyl-3-hydroxybutanoate

Ausbeute 43.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction
2. 2
   Sonstigethe enzyme was removed by filtration
3. 3
   Waschenwashed with n-heptane on a filter paper
4. 4
   workup.DISTILLATIONn-Heptane was distilled off from the filtrate
5. 5
   workup.DISTILLATIONthe residue was subjected to a vacuum distillation

Vorschrift

A mixture of a racemate, t-butyl 2-methyl-3hydroxybutanoate 30 g, vinyl laurate 40 g, and Lipase P (Amano Pharmaceutical Co., Ltd.) 8.0 g was stirred at 35° C. for 7 days. After stopping the reaction, the enzyme was removed by filtration and washed with n-heptane on a filter paper. n-Heptane was distilled off from the filtrate and the residue was subjected to a vacuum distillation to give 13 g of t-butyl (3S)-2-methyl-3-hydroxybutanoate of the following formula, ##STR25## and 23 g of t-butyl (3R)-2-methyl-3-dodecanoyloxy butanoate of the following formula, ##STR26##

Quelle