Reaktion #640592

Reaktionsgleichung

1,4-diaminobutane

3,4-difluorobenzyl bromide

cyanogen bromide

→

title compound

1,3-Bis-(3,4-difluorobenzyl)-[1,3]diazepan-2-ylideneamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas isolated upon aqueous work-up
2. 2
   Sonstigepurified by preparative LCMS

Vorschrift

The title compound was prepared from 1,4-diaminobutane in four steps by Procedure A, using 3,4-difluorobenzyl bromide as benzylating reagent. After reacting with cyanogen bromide (this step performed at 200° C. for 60 min using MW heating), the crude product was isolated upon aqueous work-up and purified by preparative LCMS to give the title compound as the free base. MS (ES+) m/z 366 ([M+1]+, 100); HR-MS: 366.1599 ([M+1]+, C19H20F4N3; calc. 366.159334).

Quelle