Reaktion #640578

Reaktionsgleichung

6-Methyl-3-(2-nitrobenzyl)-[1,3]-oxazepan-2-one

ammonium chloride

water

→

3-(2-aminobenzyl)-6-methyl-[1,3]-oxazepan-2-one

Ausbeute 60.2%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for one hour
2. 2
   Filtrationthe reaction mixture was filtered with suction
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   WaschenThe organic layer was washed with a saturated brine
5. 5
   Trocknendried over anhydrous sodium sulfate

Vorschrift

6-Methyl-3-(2-nitrobenzyl)-[1,3]-oxazepan-2-one (1.91 g, 7.23 mmol), iron powder (2.02 g, 36.2 mmol), ammonium chloride (0.19 g, 3.55 mmol) were suspended in ethanol (30 ml) and water (15 ml) and heated to reflux for one hour. After cooling to room temperature, the reaction mixture was filtered with suction and extracted with ethyl acetate. The organic layer was washed with a saturated brine and then dried over anhydrous sodium sulfate, and 3-(2-aminobenzyl)-6-methyl-[1,3]-oxazepan-2-one (1.02 g) was obtained by evaporating the solvent under reduced pressure.

Quelle