Reaktion #640551
ord-58141b0965b24d8e90d911acee886957
Reaktionsgleichung
modafinil
2-[(diphenylmethyl)sulfinyl]acetic acid
α-methylbenzyl amine
→
(−) modafinil
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
U.S. Pat. No. 4,927,855 describes the preparation of the levorotatory enantiomer of modafinil by chiral resolution of the 2-[(diphenylmethyl)sulfinyl]acetic acid with α-methylbenzyl amine. After recovery and amidation of the enantiomerically pure acid, (−) modafinil was obtained as white crystals by crystallization from ethanol.