Reaktion #640541

Reaktionsgleichung

6-aminonicotinic acid

ethanol

→

white solid

Ethyl 6-Aminonicotinate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas bubbled in dry hydrochloric acid at 0° C.
2. 2
   Temperaturthe solution was refluxed until all the solids
3. 3
   workup.DISSOLUTIONdissolved
4. 4
   SonstigeThe solvents were removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
6. 6
   Waschenwashed with saturated sodium bicarbonate, brine
7. 7
   Einengenconcentrated

Vorschrift

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

Quelle